Platelet-Strong Plasma (PRP) is the return of a small amount of blood taken from the person through a special kit and centrifugation process, and the plasma enriched from the platelet direction, back to the individual by injection. The growth factors released from these cells activate the repair systems of the cells and provide wound healing. In PRP application, much more platelets and growth factors can be delivered to the target area than can be carried by the blood circulation. When platelets, which are concentrated in the plasma, are injected into the skin, they stimulate the production of collagen and the formation of new capillaries, and allow the skin to renew itself rapidly. The PRP process starts with blood collection from the patient, the serum obtained by centrifuging at 3000 rpm in 8 minutes with a special filter; It is injected into the skin with mesotherapy and filling procedure. The most valuable advantage of the technique is that it is obtained from the patient’s own blood and does not carry the risk of allergy. Platelets and white blood cells at the injection site cause the release of heavy growth factors with a synergistic effect.
Growth hormones, cytokines, chemokines and coagulation factors released from alpha and core granules in the platelets are the most valuable elements in hemostasis, wound beautification and tissue regeneration. In order for these growth factors to take effect, they must be activated before they are released. Otherwise, damaged platelets fail in this process. Platelets are found in normal blood at a cost of about 140000-400000 per mm3. Different results in PRP applications; equipment used, protocol used to activate the platelet gel, factors related to the patient, cell size used, different storage times.
A lot of research is being done on the growth factors in the content of platelets. There are even clinical applications of some growth factors. Apart from this, they are also included in cosmetic preparations.
PRP is a system that has been used medically for 30 years. It was used following open heart surgery in 1987. Today, orthopedic interventions, dental and oral interventions, plastic surgery flap shift operations, heart bypass surgeries are used in cases requiring angiogenesis. Its primary uses in dermatology are in the care of chronic wounds, ulcers and burns. In recent years, it has been widely used in the field of cosmetic dermatology.
We use PRP treatment in dermatology clinics;
1- In wound healing
2- In skin rejuvenation
3- Fine lines and wrinkles
4- In volumetric filling process
5- In acne scarring
6- In hair loss, which we call alopecia
7- In cellulite
8- We use it in the treatment of striae (skin cracks).
We prefer it to increase wound beautification and to get an effective result, especially after laser processes related to the face. The aim here is to stimulate the old and damaged skin and subcutaneous tissues, to renew them and to produce new skin. Studies have shown sufficient results in the treatment of the nasolabial fold, which extends from the edge of the nose to the corner of the mouth.
Success rates are high when combined with fractional lasers, especially in individuals who suffer from acne and have sunken scars. In the pregnancy spots we call melasma, TGF Beta 1 factor in its content reduces the production of the color cell we call melanocytes, so it has an application area in the treatment. PRP, which was initially preferred due to strong and full hair growth after hair transplantation, is successfully applied in many hair loss types today. It is known that VEGF8 and PDGF4 in PRP facilitate strong hair growth by facilitating vascular formation.
PRP is a system preferred by dermatologists because of its high tolerability, high level of skin rejuvenation, long-lasting effect, and new and natural collagen production when used in skin regeneration.
Who is PRP treatment not applied to? We do not apply the PRP process in those with critical levels of platelet count, hemodynamic disorders, sepsis, acute and chronic infections, facial (facial) malignancies, chronic liver pathology, and those receiving anticoagulant treatments.
We achieve positive results in hair loss such as Alopecia areata, Androgenic alopecia, Telogen efflivium, either alone or in combination with mesotherapy. We increase the success of treatment by combining laser treatments in skin blemishes. With these treatment protocols, which are combined with radiofrequency and laser alone, with needle and needle-free mesotherapy methods in wrinkle and skin rejuvenation, we can ensure that your skin is healthy, shiny, skin elasticity is strong, and sagging problems are eliminated.
It is extremely valuable in terms of effectiveness that PRP treatment, which is frequently preferred by many dermatology clusters and associations, in which I am a member, is preferred in dermatological and cosmetic applications. The side effects and complications that we have seen in the media about this application reveal the necessity of this process to be done by experts every day.