Stem cells are cells that have the ability to renew themselves and turn into different cells. While it provides tissue and organ development during the period in the mother’s womb, it is used with the aim of repair and renewal in the adult period. Stem cell applications have also been added to the skin rejuvenation methods that have increased in recent years. Fat tissue; It is an endocrine organ that has cells with potential similar to bone marrow-derived cells and shines as a stem cell reserve. It consists of parts of the stromal vascular fraction, including many cells such as mature adipocytes, which make up approximately 90% of the tissue volume, and stem cells.
Stem cells in adipose tissue are more attractive because they are resistant to the phenomenon called ischemia, stem cells can be obtained in larger sizes compared to other stem cell source tissues, and because it is actually a tissue that the individual is uncomfortable with in terms of aesthetics. For this reason, in recent times, especially aesthetic applications; It has started to be used for skin rejuvenation, acne scarring, wound healing, and treatment of burn lesions. In fact, apart from aesthetics, it is also used in many areas such as infertility and musculoskeletal diseases.
How Are Stem Cells Obtained From Adipose Tissue?
The isolation route is performed under anesthesia in the operating room environment, under sterile conditions. Stem cell cocktail is obtained after the adipose tissue obtained from the abdomen with the liposuction method undergoes a series of processes such as centrifugation and flow cytometry. Stem cell capacity of the resulting cocktail; It is affected by factors such as the age of the individual (decreases as age increases), isolation conditions. It is applied under anesthesia for the areas or purpose that is requested to be applied.
Let’s Look at the Effect Mechanism, Activity and Results of Stem Cell Application:
In individuals who received stem cell vaccine; It was observed that fibroblast migration increased, an increase in collagen type 1, and melanocyte proliferation in the melanogenesis pathway through interleukin-6 cytokine inhibited proliferation and melanin synthesis. Thus; skin quality and elasticity increase, wrinkles and spots decrease. Therefore, with the stem cell vaccine technique, new vascularization, new collagen and tissue regeneration and adaptation of the skin physiology are achieved. In studies conducted on individuals with hair loss; An increase in hair density and hair shaft was observed.
Stem Cell Application
It is a very attractive application due to the use of non-foreign cells from the individual’s own body. Just like in time; Since these cells do not contain structures called HLA-DR, they are not rejected by the body. It is a single session application for skin rejuvenation, acne scars, burn scars and hair loss.
To Whom Is Stem Cell Application Not Applied?
Pregnancy, lactation, cancer patients, Hepatitis B/C patients, active infection in systemic or process areas, and individuals with a body mass index lower than 25 kg/m2 and higher than 27 kg/m2 are not eligible for this application. In the application area; Discontinuous conditions such as redness, edema, nodule and bruising can be observed. In order to prevent infection, it is recommended that the process be strictly sterile and applied on operating room bases.